Obesity typically causes a constellation of metabolic abnormalities (increased intrahepatic triglyceride content, resistance to insulin, inadequate insulin secretion by the pancreas, and atherogenic dyslipidemia [high triglycerides and low HDL-cholesterol] and increased blood pressure) that are important risk factors for type 2 diabetes and cardiovascular disease. However, not all people with obesity develop metabolic abnormalities and are protected from the adverse metabolic effects of excess fat accumulation. The precise mechanisms responsible for the development of metabolic complications in some, but not all obese persons are not known, but potentially involve differences in genes, adipose tissue biology, systemic inflammation, gut bacteria, and lifestyle factors (e.g., diet, physical activity, and sleep). This symposium will provide a better understanding of why some people with obesity are predisposed to, while others are protected from, the metabolic complications associated with excess body fat and help identify the mechanisms responsible for the link between excess body fat and disease.

1:30pm Effect of Heterogeneity of Adipose Tissue Biology on Metabolic Function in Rodent Models
Philipp E Scherer, PhD
1:50pm Heterogeneity in Multi-organ System Biology in People
Samuel Klein, MD
2:10pm Influence of Heterogeneity in Energy Expenditure and Fitness on Metabolic Health
Eric Ravussin, PhD
2:25pm Junior Researcher Presentation
Brian J Debosch, MD PhD
2:35pm Junior Researcher Presentation
Nabil Rabhi, MD PhD