Background

This study aimed to report weight loss outcomes and evaluate behaviors of high performing participants who achieved ≥10% and ≥ 15% weight loss at 6 and 18 months in a precision medicine weight loss program, which incorporates clinical visits, a mobile application (mHealth), and tailored nutritional programming.

Methods

A retrospective analysis was performed on participants, aged ≥18 years with BMI ≥25 kg/m2, who enrolled in Enara Health’s weight loss program from March 1, 2015 to October 1, 2018. Participants were matched into 6 and 18 month cohorts. An analysis characterized high-performing participants who lost ≥15% of their starting weight. Behaviors evaluated included: monthly appointments, monthly coaching text conversations, weekly food pictures, percent of educational content completed, weekly weight monitoring, and number of days wearing an activity tracker.

Results

Average weight loss for the 6 month(n=479) and 18 month(n=145) cohorts was -12.40% and -13.99%,respectively. 64.72% and 32.57% of participants achieved a 10% and 15% weight loss at 6 months. 71.72% and 41.38% of participants achieved a 10% and 15% weight loss at 18 months. High achievers at 6 months had increased monthly appointments (2.87 vs 2.51, P<.001), weekly food pictures(35.97 vs 29.37,P<.001), educational activity compliance(53..43% vs 43.73%,P<0.01), and weekly weights(3.20 vs 2.51,P<0.01). High achievers at 18 months had increased monthly appointments (2.103 vs 1.707,P<0.01), weekly food pictures(24.44 vs 18.65,P<0.01), weekly weights(1.76 vs 1.17,P<0.01), and monthly coaching text conversations(6.21 vs 4.24,P<0.01).

Conclusions

Participants in the Enara Health precision weight loss program lost an average of -13.99% at 18 months. Self tracking and increased provider-patient touch points characterized high achievers at 18 months. Mobile health applications may be better suited to achieve sustained weight loss by designing features that facilitate provider-patient interactions on top of self tracking technology.