This study aimed to report weight loss outcomes and evaluate behaviors of high performing participants who achieved ≥10% and ≥ 15% weight loss at 6 and 18 months in a precision medicine weight loss program, which incorporates clinical visits, a mobile application (mHealth), and tailored nutritional programming.


A retrospective analysis was performed on participants, aged ≥18 years with BMI ≥25 kg/m2, who enrolled in Enara Health’s weight loss program from March 1, 2015 to October 1, 2018. Participants were matched into 6 and 18 month cohorts. An analysis characterized high-performing participants who lost ≥15% of their starting weight. Behaviors evaluated included: monthly appointments, monthly coaching text conversations, weekly food pictures, percent of educational content completed, weekly weight monitoring, and number of days wearing an activity tracker.


Average weight loss for the 6 month(n=479) and 18 month(n=145) cohorts was -12.40% and -13.99%,respectively. 64.72% and 32.57% of participants achieved a 10% and 15% weight loss at 6 months. 71.72% and 41.38% of participants achieved a 10% and 15% weight loss at 18 months. High achievers at 6 months had increased monthly appointments (2.87 vs 2.51, P<.001), weekly food pictures(35.97 vs 29.37,P<.001), educational activity compliance(53..43% vs 43.73%,P<0.01), and weekly weights(3.20 vs 2.51,P<0.01). High achievers at 18 months had increased monthly appointments (2.103 vs 1.707,P<0.01), weekly food pictures(24.44 vs 18.65,P<0.01), weekly weights(1.76 vs 1.17,P<0.01), and monthly coaching text conversations(6.21 vs 4.24,P<0.01).


Participants in the Enara Health precision weight loss program lost an average of -13.99% at 18 months. Self tracking and increased provider-patient touch points characterized high achievers at 18 months. Mobile health applications may be better suited to achieve sustained weight loss by designing features that facilitate provider-patient interactions on top of self tracking technology.