The advanced glycation end products/receptor for advanced glycation end products (AGE/RAGE) system has been shown to play a pivotal role in the development of cardiovascular diseases. Obesity is associated with low levels of soluble RAGE (sRAGE) and that represents an important risk factor for the development of atherosclerosis.We evaluate the levels of sRAGE and its association with markers of cardiovascular risk factors in children with obesity.
A cross-sectional study in children (6-11 years old) with obesity. Anthropometric measurements, AGEs consumption, glucose, lipid profile, insulin, and sRAGE levels were evaluated, body mass index (BMI), TC/HDL, LDL/HDL, TG/Glucose, TG/HDL-C index, HOMA-IR was calculated. Each child completed a 24-hour dietary recall (two from the week and 1 on the weekend) with help from their parents. Total AGEs intake was calculated according to tables of Uribarri et al. The study was approved by the Institutional Committee for Bioethics in Research of the University of Guanajuato.
Eighty children were studied with a mean of age 9.2 ± 1.3 years. The girls showed greater waist girth (p=0.003), HOMA-IR (p=0.00001), TG/Glucose (p=0.03) and TG/HDL-C index (p=0.03) and no significant differences for diet AGEs and sRAGE, According to the tertiles of TG/HDL index; we found higher levels of CT/HDL (p<0.0001), TG/Glucose index (p<0.0001), and sRAGE (p=0.03) in the upper tertile. In the female gender, we found a significant correlation of age (p=0.006), BMI (p=0.04), Waist girth (p=0.02), TG/GLU index (p=0.002) and sRAGE with TG/HDL (p=0.01) and TG/Glucose index (0.01).
In our group of study the female show higher cardiovascular risk factors, the upper tertile TG/HDL index showed higher levels of sRAGE a new emerging marker which could predict subjects at increased risk of developing metabolic and cardiovascular complications.Grant: Partially supported by the University of Guanajuato (DAIP-2019)