Improvement of obesity and related comorbidities is a beneficial outcome of bariatric surgery. The impact of laparoscopic sleeve gastrectomy (LSG) on serum prolactin (PRL) levels, especially in Chinese severely obese patients is unexplored. We aimed to assess the changes of serum PRL levels and their correlation with insulin resistance (IR) and β-cell function.


We prospectively enrolled 168 severely obese subjects [68% women; mean body mass index (BMI) 44.3±6.6 kg/m2] who underwent LSG between June 2012 and February 2019. PRL, homeostasis model assessment of insulin resistance (HOMA-IR), area under the curve (AUC) of glucose (AUC glucose) and insulin (AUC insulin), homeostasis model assessment of β-cell function (HOMA-β), insulinogenic index (IGI), deposition index (DI), and insulin sensitivity index (ISI) were compared at baseline and 12 months following LSG.


At baseline, the hyperprolactinemia was more common in females than males. Twelve months after LSG, there was significant increase of PRL in males but nonsignificant reduction in females. In addition, we observed a significant decrease in HOMA-IR, AUCglucose and AUCinsulin, as well as a significant increase in HOMA-β, IGI, DI, and ISI in both genders. The linear regression analysis showed a marked correlation of increased PRL and decreased HOMA-IR and increased HOMA-β in males but no significant correlation were observed between changes in PRL and changes in related metabolic indexes in females after adjusting for baseline BMI, changes in BMI, and other metabolic factors.


LSG promotes a significant increase in males but nonsignificant changes in females. The increased PRL levels in males were correlated with improved IR and increased β-cell function. Further researches are needed to confirm these findings.