Obesity is a multifactorial disease with many risks to public health, with 39.6% of American adults and 18.5% of young people obese. Brazil ranks fifth in the world ranking, with about 18 million people. In this scenario, melatonin has evidenced an important function in the regulation of energy metabolism. Information gap: What is the real influence of melatonin supplementation on obesity control? Thus, the aim of the present study was to perform a systematic review followed by a meta-analysis of randomized clinical trials over the past ten years to explore the efficacy and safety of melatonin for weight reduction.


The PRISMA rules followed. The descriptors melatonin, obesity, metabolism and clinical study were used.


The results were significant that imbalance of melatonin can lead to metabolic disturbances and circadian rhythmic disorders, p <0.05 (R2 = 94.5%).


Melatonin is important for energy regulation, but further studies of its supplementation in the control of obesity are needed.